These games depict biological processes run amuck, rampant mutation, and bodily fusion with mechanical or eletronic elements. Obvious sources of inspiration are Invasion of the Body Snatchers (1978), Alien (1979), Akira (1982), The Thing (1982), or Jacob's Ladder (1990).
Metroid
NES
1986
@1271Life Force
NES
1987
@1454Aliens
Arcade
1990
@421Space Gun
Arcade
1990
@326Amnios
Amiga
1991
@725Super R-Type
SNES
1991
@231R-Type III: The Third Lightning
SNES
1993
@181Alien 3: The Gun
System 32
1993
@819Super Metroid
SNES
1994
@115Alien vs. Predator
CP System II
1994
@726Silent Hill
PlayStation
1999
@105Silent Hill 2
PlayStation 2
2001
@106Metroid Prime
GameCube
2002
@34R-Type Final
PlayStation 2
2003
@42Silent Hill 3
PlayStation 2
2003
@490Silent Hill 4: The Room
PlayStation 2
2004
@39R-Type Tactics
PSP
2007
@49Silent Hill: Origins
PSP
2007
@397Dead Space
Xbox 360
2008
@1Alien Crush Returns
Wii
2008
@795Silent Hill Homecoming
Xbox 360
2008
@156Silent Hill: Shattered Memories
Wii
2009
@255Dead Space 2
Xbox 360
2011
@261Dead Space 3
Xbox 360
2013
@537The Last of Us
PlayStation 3
2013
@621The Last of Us Remastered
PlayStation 4
2014
@1855Soma
PlayStation 4
2015
@1487Inside
Xbox One
2016
@1614Inside
Windows
2016
@1637Inside
PlayStation 4
2016
@1678Gears of War 4
Xbox One
2016
@1724Gears 5
Xbox One
2019
@2272SAR: Search and Rescue
PlayStation 4
2019 (orig. 1989)
@2345Carrion
Xbox One
2020
@2693R-Type Final 2
PlayStation 4
2021
@2795