After a bit of research, I got MAME to emulate a Sharp X68000 and run this game. I had to have a BIOS file named 'x68000.zip' in the 'roms' dir and run the emulator with a command-line like this:
mame x68000 -flop1 disk1.zip -flop2 disk2.zip
6486
Very important feature when emulating computers in MAME: Scroll Lock toggles keyboard modes between emulated keys and MAME shortcut keys.
